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Treatment with ganaxolone, a positive allosteric modulator of GABAA receptors, improves behavioral deficits in mice with specific Shank3 gene knockout in PV-positive neurons (96)
Immobilized thiaminase II has been applied as an anticancer approach to deplete thiamine in cancer cells (176)
4 , PO.19.00264 (2020)
The depth of chemical time and the power of enzymes as catalysts
Going straight to maintenance doses means tissue concentrations never reach therapeutic threshold
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