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It is why using a backup barrier method is required

Despite distinctive ligand recognition and receptor activation mechanisms, the G i -coupling mode of GHSR is highly similar to those of other closely related neuropeptide GPCRs such as neurotensin receptors (NTSRs) 42

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Company-reported Phase 3 topline results have circulated in 20252026, and a regulatory filing has been anticipated, but retatrutide is not FDA- or EMA-approved and is not available as a prescription product