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If a drug is given in solid form, then the drug must first break down into smaller particles (disintegration) and dissolve in the medium in which it is administered (dissolution) before it can traverse the cell membrane (permeation) and enter the bloodstream (absorption), Fig

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Skin is the biggest organ of the human body, which provides maintenance of bodily fluid homeostasis and acts as a physical barrier against the entry of microorganisms [39]

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It carries the CAS registry number 137525-51-0 and the molecular formula CHNO