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In the liver, glucagon receptor activation promotes gluconeogenesis and fatty acid oxidation
It is provided as a lyophilized peptide powder to support stability and controlled reconstitution for experimental use
It does both
Accordingly, in vitro and ex vivo studies have shown that exposure to saxagliptin (135, 136) but not sitagliptin (136), results in altered cardiac electrophysiology and is associated with impaired cardiomyocyte contractility
Overall, LNAs good stability, high binding specificity, and strong nuclease resistance make it advantageous for in vitro and in vivo applications
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