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Further analyses showed that A2V reprograms the TME by shifting TAM polarization from protumor M2 toward antitumor M1with expansion of M1 subsets, reduction of M2 subsets, and a net increase in the M1/M2 ratiowithout requiring T-cell participation and involving both circulating monocyte-derived macrophages and resident microglia [48]

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Defining the dominant ROS source(s) and downstream transcriptional factors in this setting will provide important directions for future work

Examined in the published literature on incretin signalling, glucose handling and energy balance

Dissolve in bacteriostatic water or the aqueous buffer required by the assay