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An injectable TME-responsive nanocomposite hydrogel incorporating IL11R-targeted liposomes has also been developed for local delivery of cisplatin-loaded MnO2 along with a MYC inhibitor, enabling sustained drug release and reshaping of the immune microenvironment in MYC-amplified osteosarcoma (45)

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IGF-1 LR3 enhances bone health and formation Data from clinical trials shows that IGF-1 LR3 stimulates bone formation via direct effect on osteoblasts, as well as having significant anabolic activity and bone protective effects

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