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[1] [2] It belongs to a class of medicines called glucagon-like peptide-1 (GLP-1) receptor agonists , which work by mimicking the action of the natural hormone GLP-1

For retatrutide, the 12 mg dose produced 28.7% weight loss but 18.2% discontinuation, while the 9 mg dose achieved 26.4% weight loss with 12.2% discontinuation

Shabani Z, Rahbarghazi R, Karimipour M, Ghadiri T, Salehi R, Sadigh-Eteghad S, et al

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While kinase activity was generally conserved across drug treatments, the magnitude (fold enrichment compared to vehicle) and trend of substrate enrichment varied greatly (Fig