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Side Effects and How They Are Managed The most common side effects are gastrointestinal, most pronounced during dose escalation and typically improving as the body adjusts: Nausea, the most frequently reported effect, particularly in the first few weeks Vomiting, though less common than nausea Diarrhea or constipation depending on the individual Decreased appetite, which is both a side effect and part of the therapeutic mechanism Mild fatigue during the early adjustment period Slow dose titration is the primary strategy for managing side effects

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