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This study demonstrated the importance of combined GLP-1R and GCGR signalling, as administration of the balanced co-agonist to Glp1r -/- mice led to hyperglycaemia, further demonstrating the necessity of GLP-1R and GCGR co-agonism to minimise this predicted side-effect
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Pituitary Stimulation : CJC-1295 mimics the action of natural GHRH and binds to the GHRH receptor in the pituitary gland, stimulating the release of GH into the bloodstream
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