Liraglutide and cardiovascular outcomes in Type 2 diabetes
Key safety findings from the STEP UP trial: Gastrointestinal events: 70.8% with 7.2 mg vs 61.2% with 2.4 mg vs 42.8% with placebo Severe GI events: 3.4% with 7.2 mg vs 3.5% with 2.4 mg Dysaesthesia (abnormal skin sensations): 22.9% with 7.2 mg vs 6.0% with 2.4 mg Stopping medication due to side effects: 5.4% for 7.2 mg vs 4.0% for 2.4 mg The higher rate of dysaesthesia (tingling or numbness sensations) at the 7.2 mg dose is worth noting
Materials and methods Participants All patients ( n =114) were recruited as part of the Monitoring Recovery from an Episode of Severe Mental Illness (RECOVERY) study in the greater BaltimoreWashington, D.C
doi:10.1016/0361-9230(87)90069-4
One of the things where for me, the rubber really met the road with this was its one thing to talk about weight, health and to talk about the weight, health, hormones, and its another to be able to actually evaluate their function, and because they only stay on for 2 to 5 minutes, I was talking to a bunch of individuals about the research and they were like, you know, actually the research is really hard because we cant show whats happening to your own hormones
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