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In glucose deficient hepatocytes, the glycolytic enzyme PFK-1 (encoded by the PFKL gene) is phosphorylated

The practical consequence for someone without diabetes is that they are being treated under a label written for a different population, at a dose ceiling set for glycemic control rather than weight reduction

An important feature of the technology is that, depending on the physicochemical properties of the nanoparticles, the drug molecules can be taken up preferentially by the blood circulation (smaller molecules) or first via lymphatic absorption (larger molecules)

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"It can affect whether they seek care, whether they talk openly with providers and how they manage their health overall." Though GLP-1s have often been described as a boon to managing obesity rate in the U.S., the idea that they are an "easy way out" persists, said Standen and fellow study authors Sean Phelan, professor of health services research at the Mayo Clinic, and Janet Tomiyama, professor of psychology at the University of California, Los Angeles