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Abbreviations: I.U

The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)

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Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-m)

Early changes often involve appetite reduction and feeling full sooner, while visible weight loss usually unfolds gradually over months rather than weeks