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We noted no significant differences in RPS15 protein levels across genotypes in young pre-leukemic mice (Supp Fig
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Rottlerin is also known to be an aggregator, 32 this led us to suspect that our USP8 assay may be susceptible to identifying molecules that can form aggregates and displaying them as false positives
The good news is that most common side effects are manageable and time-limited
In combination with insulin, some studies have shown a reduction in hypoglycaemic episodes due to a reduction in the insulin dose
Additionally, due to the heat from the ultrasound, the skin will be more prone to dryness and sunburn after the treatment
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