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Over a period of time, cells that are exposed to continuous signaling can downregulate their receptors as a protective mechanism

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du Halgouet, A

Tumor targeting peptide TMTP1 modified antigen capture nano-vaccine combined with chemotherapy and PD-L1 blockade effectively inhibits growth of ovarian cancer

Cell Proliferation and Neoplastic Concerns Theoretically, any growth factor that promotes cell proliferation raises theoretical concerns about uncontrolled growth and neoplastic transformation