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When to Expect Noticeable Changes and How to Track Progress Most patients notice a shift in appetite by days 714 of treatment

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Meta-analyses have shown that the amount of weight regained after stopping treatment is typically proportional to the initial weight loss, and lifestyle interventions become increasingly difficult to maintain once the medication is discontinued ( 10 Expanding the use of GLP-1RAs to treat substance use disorders To date, only a limited number of clinical trials have evaluated the effectiveness of GLP-1RAs for substance use disorders, yet initial findings are encouraging

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