Remarkably, the two top enriched GO terms within the top 100 differentially regulated genes in hematopoietic stem cells from Aldh2 / Adh5 / mice correspond to cellular response to oxygen-containing compounds (GO1901700 and GO1901701) 10 , suggesting oxidative stress might play an important role in the onset of IBMFS/AMeD phenotypes
The fact that we did not observe an antiviral effect in the lower respiratory tract underscores the need of further treatment optimization before its potential evaluation in humans
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It is found in human blood, saliva, and urine, with plasma levels declining from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60