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Huntingtons disease: latest Frontiers in therapeutics
Nardone OM, de Sire R, Petito V, Testa A, Villani G, Scaldaferri F, et al
However, nanotechnology can enhance the antioxidant effect by preparing nanoparticles as carriers for these antioxidants, allowing for targeted and controlled release (193)
Is the failing heart energy depleted
In a study utilizing Ex-4-loaded nanotube-fiber matrices, the scaffolds demonstrated excellent cytocompatibility, supporting cell attachment and proliferation regardless of whether Ex-4 was embedded within the matrix or supplied exogenously through the culture medium
Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)
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