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Metabolic and bariatric surgery should be discussed with patients who have BMI 35 kg/m (regardless of comorbidities) or BMI 30-34.9 kg/m with metabolic disease, according to 2022 ASMBS/IFSO guidelines

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It reinforces the GH pulse by inhibiting somatostatin (the hormone that suppresses GH) and directly stimulating the pituitary to release stored GH

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