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doi:10.1053/j.gastro.2014.03.045 [PMC Full Text] [PubMed] [Crosslink] McGill MR, Jaeschke H
Cycle Rationale Cycle rationale involves: Preventing receptor desensitization Allowing body to reset natural peptide production Maintaining copper balance to avoid accumulation Optimizing long-term efficacy Vial Requirements Per Cycle For 50 mg vials at 1-2 mg daily dosing: 2-3 vials (84-168 mg total) 3-4 vials (126-252 mg total) 4-5 vials (168-336 mg total) Storage Requirements Lyophilized powder storage optimally occurs at -20C (freezer) until reconstitution, with alternatives of 2-8C (refrigerator) or cool, dry place
Androgens have been shown to downregulate the expression of bile-salt export pump (BSEP) and multidrug resistanceassociated proteins (MRPs), resulting in bile-acid retention and cytotoxic accumulation within hepatocytes
notably, metformin non-users experienced numerically higher gastrointestinal event rates
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