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Reported activities include fibroblast stimulation, controlled intracellular copper delivery, modulation of collagen and glycosaminoglycan synthesis, and broad changes in gene expression across stress-response and tissue-repair networks
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10.1093/nar/gks1094 27 FuJ
However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])
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Fermented foods that support gut health, such as yoghurt and kefir A balanced diet that supports gut health may help optimise natural GLP-1 activity
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