Additional risk factors include: Previous significant weight fluctuations or yo-yo dieting Genetic factors affecting skin quality and collagen production Smoking history, which impairs skin elasticity Inadequate protein intake during weight loss, leading to muscle loss Insufficient resistance exercise to maintain muscle mass Dehydration or poor nutritional status Patients with multiple risk factors should discuss realistic expectations with their GP or diabetes specialist nurse before commencing semaglutide therapy
Semaglutide, which is the active ingredient in Novo Nordisk's Wegovy and Ozempic, as well as tirzepatide, which is the active ingredient in Eli Lily's Mounjaro and Zepbound, are considered GLP-1 drugs
However, practical considerations exist
Semaglutide has demonstrated improvements in CV death, stroke and myocardial infarction
A sudden reduction in body weight can also lead to the sagging of the skin
Ginger can help speed up gastric emptying, while peppermint can help relax the muscles of the esophagus and stomach, allowing gas to pass more easily (though use peppermint with caution if you also suffer from acid reflux)