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Konig SA, Siemes H, Blaker F, Boenigk E, Gross-Selbeck G, Hanefeld F, Haas N, Kohler B, Koelfen W, Korinthenberg R, et al .: Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities
doi: 10.1186/S12940-023-01045-Z 54
In contrast, under alkaline conditions, the B-ring hydroxyl group of PCs becomes vulnerable to oxidation, resulting in a decrease in their antioxidant activity (40)
The risk is greatest among infants who are fed formula low in biotin, people taking antiepileptic medications, infants with Leiners disease or people who are genetically predisposed to deficiency ( Untreated biotin deficiency can cause neurological symptoms, such as seizures, intellectual disability and loss of muscle coordination ( Deficiency has also been reported in animals fed high amounts of raw egg whites
About 5 million Americans have it, with diabetes and post-surgical causes being the most common identifiable triggers
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