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However, the combined effect of multiple BDNF-boosting compounds on total TrkB activation has not been systematically studied, so conservative dosing is advisable

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Once under NIR stimulation, the oxygen-sensitive linker connecting the siRNA and pASO facilitates the endo/lysosomal escape of the released siRNA and pASO, enabling them to reach their cytosolic targets

Additionally, certain peptide sequences may be recognized as foreign by the immune system, increasing the likelihood of unwanted immune reactions

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