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The problem, it seems, is that catalase and other antioxidant defenses may decline as we age, and leave melanocytes vulnerable to their own hot-potato production of pigment

Based on the crucial role that ROS play in the pathology and pharmacological treatment of a wide range of diseases, therapeutic strategies targeting the regulation of ROS homeostasis hold significant clinical value for revealing the molecular mechanisms of diseases, promoting drug development, and advancing personalized treatment

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The gut-liver axis becomes pathologically altered in NAFLD due to increased intestinal permeability, enabling translocation of microbial products into the liver and exacerbating inflammation

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This can also lead to a larger than normal liver, low blood sugar, lactic acid build up, high ammonia levels in the blood, and increased amounts of certain liver enzymes