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[1] [4] The large-scale randomised controlled trials, including the SUSTAIN and STEP programmes, were not specifically designed to assess sex hormone profiles as outcomes, and there is no signal of a direct oestrogen-lowering effect to date
About this article Cite this article Chitolina, R., Reis, C.G., Stahlhofer-Buss, T
Also seek prompt medical advice if you develop right upper abdominal pain, yellowing of the skin/eyes (jaundice), cannot keep fluids down for more than 24 hours, or notice markedly reduced urine output
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Each works through a different mechanism, and the evidence levels are very different
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