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That is, xCT inhibitors may exhibit anticancer properties against cancer cells with elevated GLUT1 expression in a high-glucose tumor environment, whereas glucose deprivation blocks ferroptosis-induced cell death [18,19] [Figure 2B]

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Excessive ROS can be detoxified by antioxidants (enzymes and non-enzymes) and in reactions catalyzed by superoxide dismutase (Cu-SOD, Zn-SOD, and Mn-SOD), GPX and catalase

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