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Strategies to mitigate lean muscle loss while on treatment include optimising dietary protein, recognising that GLP-1 and GIP/GLP-1 receptor agonists may suppress appetite and substantially reduce overall energy intake, increasing the risk of inadequate protein consumption.260-262 Regular resistance exercise training can help preserve lean muscle mass during weight loss and should be performed on two or more days per week, where clinically appropriate.159 Dietary advice for people on incretin-based medications Incretin-based medications increase the risk of muscle loss, sarcopenic obesity and nutrient deficiencies
The ADA has adopted these recommendations in their annual recommendations Standards of Medical Care in Diabetes in 2019 (72)
Moreover, successful data integration for translational applications is essential
Peptide approaches aim for slower, self-regulated change
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