Semaglutide and retatrutide both activate GLP-1 receptors, which help lower appetite, slow digestion, and support blood sugar regulation after eating
Earlier observational studies also found links between GLP-1 treatment and lower risks of alcohol and cannabis use disorders, opioid overdose, and alcohol-related hospitalization
While highly effective, injections can be a psychological or logistical barrier for many patients, limiting adoption and long-term adherence
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Zepbounds range of available doses (from 2.5 mg to 15 mg) gives significant room for adjustment
However, some major insurance companies are known to be more flexible with GLP-1 approvals