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Alhadeff estimates that about two-thirds of patients deal with nausea as a side effect, and a 2025 study found that GLP-1 drugs side effects such as nausea are greater in those with better taste and smell. (Is this confirmation that Im a super-smeller and super-taster?) My nausea in the initial months of GLP-1 medication usage means it could be part or all of the reason I have such a visceral reaction to specific scents
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For the earlier window mild cognitive impairment (MCI) and brain aging where synaptic loss is the dominant driver of symptoms and where the 2026 NICE rejection of lecanemab and donanemab has left a substantial UK treatment gap, the synaptic-rationale conversation continues even after the fosgonimeton failure
The MHRA and EMA continuously monitor the safety of these medications, and patients are encouraged to report suspected side effects via the MHRA Yellow Card scheme
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"Clinical activity of folinic acid in patients with chronic fatigue syndrome"
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