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Some case reports showed GLP-1 treatment damaged reproduction function in one patient ( The reproductive action of TGF- extends to steroidogenesis as it was reported to downregulate the expression of LH and hCG receptors and in turn decrease hCG-induced testosterone production in Leydig cells and it was also reported to decrease steroidogenic genes expression as StAR and P450c17 ( 5 Conclusion The central and peripheral molecular pathways involved in diabetic-induced male testicular dysfunction in rats are complex and multifactorial and involve several different cellular and molecular mechanisms

In contrast, excessive or sustained activation of TLRs can promote chronic inflammation and has been implicated in the pathogenesis of numerous immune-mediated disorders (262)

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Am J Clin Nutr 109:14021413

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