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Brain research, 583(1-2), 194200.

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Nevertheless, the administration of high doses of progestins may lead to adverse effects such as thrombosis, hyperglycemia, and edema

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It modulates inflammation by regulating the production of pro-inflammatory and anti-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-) and interleukin-10 (IL-10) (Drge & Breitkreutz, 2000)