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It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acids synthesis and energy production
The trial did not meet its primary efficacy endpoint for weight loss [3]
NNMT inhibition reduces one methylation pathway, but it doesn't directly deplete systemic methyl donorsit redirects nicotinamide away from methylation toward NAD+ salvage
The Endocrine Society's 2023 clinical practice guideline on obesity pharmacotherapy states: "Pharmacological treatment of obesity in adolescents should use agents with demonstrated safety and efficacy in randomized trials conducted in this age group" [12]
MIC injections are not FDA-approved for weight loss
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