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FOXO4-DRI's ability to selectively eliminate these cells provides researchers with tools for studying how senescent cell burden contributes to aging phenotypes and age-related diseases
Several other trials are assessing the safety and efficacy of tirzepatide in improving different cardiometabolic complications such as OSA, MASH and heart failure with preserved ejection fraction (HFpEF) (NCT05412004, NCT04166773, NCT 04847557) [16]
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The semaglutide titration protocol used in the STEP trials and embedded in the Wegovy prescribing information is designed to bring researchers to the 2.4 mg maintenance dose over 16 weeks while keeping gastrointestinal side effects manageable
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