can you take tirzepatide if you have hypothyroidism (Mounjaro) be used safely in a patient with hypothyroidism? Tirzepatide and Thyroid Nodules: Safety

Administer the concomitant oral medication at least 1 hour prior to SYMLIN injection or 2 hours after SYMLIN injection if the rapid onset or threshold concentration of the concomitant medication is a critical determinant of its effectiveness (such as with analgesics, antibiotics, and oral contraceptives) [see Drug Interactions (7.2) and Clinical Pharmacology (12.3)]

Phase 2 trial data shows that nausea occurred in 14% of participants at the 1mg dose but jumped to 45% at the 12mg dose

Importantly, both dietary interventions negatively affected bone mass and mechanical strength

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Dysaesthesia has been reported in some clinical trials of semaglutide, including the STEP UP T2D trial of subcutaneous semaglutide, results of which showed that the adverse effect was more common with 7.2 mg doses (n=58 [18.9%] of 307) compared with 2.4 mg doses (n=five [4.9%] of 103)

These alternatives typically show lower efficacy than GLP-1s but provide meaningful benefits at reduced cost