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Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes

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"Glutathione: new roles in redox signaling for an old antioxidant." Frontiers in Pharmacology

We further excluded individuals with a history of treatment with insulin before their initial prescription for a non-insulin glucose-lowering drug (since insulin therapy at baseline is considered for patients with advanced disease), women with a history of polycystic ovary syndrome or gestational diabetes, and individuals with type 1 diabetes

Many patients maintain benefits with monthly or biweekly sessions