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Progestogens: These include norethisterone, oral medroxyprogesterone acetate, depot medroxyprogesterone acetate (DMPA), and the levonorgestrel-releasing intrauterine system (LNG-IUS, e.g., Mirena)

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These therapies improve insulin sensitivity, regulate blood sugar, reduce appetite, and increase fat-burning efficiency

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While Wegovy has established a reliable foundation with average weight loss of 15% to 17%, and Mounjaro has pushed these boundaries to 22.5%, Retatrutide achieves an average of 24.2% over 48 weeks at its highest dose