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Interestingly, the mutation of ATP4Ap.R703C leads to gastric acid deficiency, and the disturbance of pH balance can directly affect the physiological function of the mitochondrial respiratory chain, causing ROS signaling to be activated and triggering caspase-3-mediated apoptosis in the host cells (Bentez et al., 2020)
Journal of the European Academy of Dermatology and Venereology (2022)
Wu (2012) J
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Such ligand-induced dimerization model has been observed in the activation of c-MET by a bacterial c-MET agonistInlB 31 , as well as in the activation of many other RTKs, such as PDGFR and VEGFR 32,33
