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This was an open-label study (no placebo group), but the high percentage of responders and magnitude of improvement were notable
Schematic representation of the cell signaling pathways that are activated by GLP-1R stimulation and that exert the neuroprotection against insults that modeled stroke (see Figure 1)
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Long-acting agents seem to have a lower incidence of gastrointestinal adverse effects (166), likely due to tachyphylaxis in gastric emptying with sustained GLP-1R stimulation
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