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Our proposed mechanism for the passive membrane permeation of semaglutide is substantiated by accurate C p HMD atomistic models (with all weakly ionizable functional groups in both the peptide and all the permeation enhancers modeled with C p HMD)

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This is information we did not have before and it should be included in discussions between patients and their doctors, especially if patients have other known optic nerve problems like glaucoma or if there is preexisting significant visual loss from other causes." This study underscores the need for cautious use of semaglutide, particularly among patients at risk of eye conditions, and highlights the importance of ongoing research to fully understand the drug's implications