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It has been shown that LH surge induces rapid methylation of steroidogenic acute regulatory protein (STAR), cytochrome P450 side-chain cleavage enzyme (CYP11A1), and 3beta-hydroxysteroid dehydrogenase (HSD3B) that are critical in progesterone production (83)
Some protocols use an extended break matching the cycle length (8 weeks on, 8 weeks off)
PMID 21653539
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Oxygen reactivity of PutA from Helicobacter species and proline-linked oxidative species
10.1038/s41568-019-0187-8 244 SapienzaC.IssaJ
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