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Since PTPs normally terminate signaling by dephosphorylating kinases, their inhibition results in prolonged phosphorylation of Src family kinases such as Lyn and Fyn, as well as downstream effectors like Syk (Jang et al., 2014)

Aside from Novo and Lilly, Boehringer Ingelheim is developing survodutide, a dual glucagon/GLP-1 receptor agonist, for MASH