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The SURMOUNT-1 trial was a 72-week, phase 3, randomized, double-blind, multicenter clinical trial that evaluated three tirzepatide doses vs

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Current prescribing information includes warnings related to elevated IGF-1, glucose intolerance, fluid retention, malignancy risk, hypersensitivity, and injection-site reactions. A complete safety discussion belongs in a separate article, but these limitations are essential when interpreting potential benefits

e , Reported pEC 50 values for each peptide agonist

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