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Sources: Aoi W, Ogaya Y, et al
Temporal and subgroup disparities in mediation effects on cardiovascular outcomes with liraglutide and semaglutide: post-hoc analysis of LEADER and SUSTAIN-6
& Grll, H
Others are engineered to cross the blood-brain barrier and directly engage GLP-1 receptors in the brain, amplifying appetite-suppressing effects
Drinking large amounts of alcohol will reduce the biological half-life of water in the body
NICE guidance recommends tirzepatide at a BMI 35 kg/m 2 with one weight-related co-morbidity, but the NHS in England is not likely to meet that goal for another 12 years, with a much more restrictive initial criteria of a BMI 40 kg/m 2 and four out of a list of five co-morbidities
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