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doi: 10.1158/1535-7163.Mct-22-0282 102 RaczkaAMReynoldsPA

The clinical analog already exists

Tissues were incubated in enzyme mix (Miltenyi Biotec, spleen dissociation kit, 130-095-926) at 37 C for 1530 min with agitation every 5 min to promote enzymatic digestion of extracellular matrix proteins

Nat Rev Neurosci 14(9):593608 Bamji SX, Majdan M, Pozniak CD, Belliveau DJ, Aloyz R, Kohn J, Causing CG, Miller FD (1998) The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

The key is individualized dosing and medical oversight

It is easier to prevent a pain spike than to bring it down once it has built up