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FOXO4 is localized within the promyelocytic leukemia body in senescent cells and interacts with p53, inhibiting its nuclear exclusion 34

Alternatively, acetylcarnitine, produced in excess in mitochondria by CrAT, is transported into cytosol by CACT and enters the nucleus, where a nuclear CrAT converts the acetylcarnitine to acetyl-CoA 67 , and it becomes a source of acetyl groups for histone acetylation

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Tirzepatide demonstrated significant reductions in HbA1c and body weight without an increased risk of hypoglycemia