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However, adding even light movement can improve results and provide additional health benefits beyond weight loss
It found no clinically meaningful differences between semaglutide and placebo on these measures
The peptide is particularly sensitive to heat, and exposure to temperatures above normal refrigeration accelerates degradation significantly
Common GLP-1 Side Effects Commonly reported semaglutide side effects include: Nausea Vomiting Diarrhea Constipation Abdominal pain Reduced appetite Bloating or fullness Indigestion Dizziness Fatigue Symptoms, Possible Concerns, and Related Tests Safety note: Severe abdominal pain, inability to keep fluids down, very low urine output, jaundice, facial or throat swelling, difficulty breathing, confusion, or sudden vision changes should not wait for routine outpatient lab testing
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The article gives a pharmacological reason: lower initial doses establish tolerance to GLP-1 agonism, which reduces nausea and vomiting during the early weeks
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