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The results demonstrated a very strong accumulation of ROS inside the hypoxic cancer cells upon treatment with NP4 but a poor ROS accumulation upon preincubation with NAC and subsequent treatment with NP4 (flow cytometry plots: Fig

To verify the role of targeting ligands in the cellular uptake process, alanine and GSH were added at high concentrations during the uptake assay of the targeted nanocarriers

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[26] None of the studies reported significant adverse effects or follow-up beyond the study period (Table 1)

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