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Kirkwood JM, Ibrahim JG, Sondak VK, Richards J, Flaherty LE, Ernstoff MS, Smith TJ, Rao U, Steele M, Blum RH: High-and low-dose interferon alfa-2b in high-risk melanoma: first analysis of inter-group trial E1690/S9111/C9190
3-AP will spontaneously convert to the toxic compound acrolein
These pharmacies charge appropriate prices reflecting proper manufacturing, testing, and quality control
doi:10.1124/jpet.110.171983, PMID: 20876229 Giorgi C, Baldassari F, Bononi A, Bonora M, De Marchi E, Marchi S, Missiroli S, Patergnani S, Rimessi A, Suski JM, Wieckowski MR, Pinton P (2012) Mitochondrial Ca(2+) and apoptosis
Plateau and declining effectiveness affect some long-term users
At therapeutic dose: Safely metabolized in the liver At high dose: Excess paracetamol Converted to toxic metabolite NAPQI NAPQI Depletes glutathione Hepatocellular necrosis Acute liver failure Serious ADRs: Hepatotoxicity Elevated liver enzymes Fulminant hepatic failure Antidote: N-acetylcysteine (NAC) most effective when given early
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