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GLP-1 receptor agonists improve metabolism by enhancing insulin secretion when blood glucose is elevated, suppressing glucagon to reduce liver glucose production, slowing gastric emptying to prevent blood sugar spikes, and increasing satiety to reduce food intake
Since then, breakthroughs have occurred in the field
23 A combination of these data with a meta-analysis 3 reviewing rosiglitazone use, which showed a 43% increase in the rate of myocardial infarction (p=0.003) and a 64% nonsignificant increased risk of CV death (p=0.006) in patients using the drug, ultimately compelled the FDA to take immediate action toward changing the standard requirements for documenting safety of new medications seeking approval for T2DM treatment
To this end, we plan to examine the role of specific insurance design features in continuous access to AOM as well as interventions to help increase persistence in the future.