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Strong oxidizers can degrade copper peptides

GLP-1 drugs also reduced related hospital admissions by 26% versus the SGLT-2s, related deaths by 50%, drug overdoses by 39%, and suicidal ideation or attempt by 25%

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This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

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10.1038/nrgastro.2012.225 122 ZhangX